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Foliage. When hyperglycemia is improved, the rate of protein glycation (SOD in this case) can be slowed down. ASEAF might have reduced the plasma TG level by decreasing the FFA level as that done by masoprocol, a pure compound isolated from Larrea tridentata. The leaves are used as a vegetable. [13], 0.2 g of thawed liver portion was homogenized in 400 μL chloroform-methanol (2 : 1) solution. In the present study, we further explored the antidiabetic potential of the crude ethanol extract and identified the active fraction which is responsible for the antidiabetic effect as well as the physiological mechanism of antidiabetic action. It is adapted to grow on a range of soil types ranging from poor sandy or alkaline soils, to loam or black cotton soils. Red List Category & Criteria: Least Concern ver 3.1 Year Assessed: 2010 Assessor/s: Gupta, A.K. Plasma and serum samples were prepared from the blood samples collected according to the instructions provided in the assay kits. Thus, preserving the function of SOD would no doubt reduce the oxidative damage to the pancreatic β cells and maintain the normal function of the β cells in insulin biosynthesis and secretion. Neutral: On Nov 22, 2006, frostweed from Josephine, Arlington, TX (Zone 8a) wrote: Sessile Joyweed Alternanthera sessilis is … ASEAF reduced the plasma FFA level, halting the worsening of the diabetic condition in the rats. Alternanthera sessilis. Also, isolation and identification of the bioactive compound(s) that responsible for the antidiabetic effect are in progress. Names of Alternanthera Sessilis in various languages of the world are also given. The organs harvested were washed with saline solution and stored at −80°C until used. The solution was left to stand at −20°C overnight and centrifuged at 3000 rpm at 4°C for 15 minutes in the next day. The homeostasis model assessment (HOMA) and quantitative insulin sensitivity check index (QUICKI) were calculated according to Cacho et al. Three fractions (hexane, ethyl acetate, and water) were obtained from the crude ethanol extract of Alternanthera sessilis Red. It is used as an aquarium plant. Paired and unpaired Student’s t-test was conducted using SPSS 17.0. When ASEAF increases peripheral insulin sensitivity, lipolysis is suppressed, and FFA level is reduced. Terpenoids are known to possessed antioxidative capacity [23]. For the preparation of serum samples, the blood sample collected was first allowed to clot for 30 minutes at room temperature. The cultivar of this plant has red instead of green aerial parts. Alternanthera sessilis/Gudri sag/ Ponnanganni is used for medicinal purpose not in Indian traditional medicine system but also in many countries of Africa. The low dose of STZ injected to the insulin resistant rats produced frank hyperglycemia which mimics human type 2 diabetes. B. Jenkins, E. A. Daley, D. J. Chisholm, and L. H. Storlien, “Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats,”, G. Boden, P. She, M. Mozzoli et al., “Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-, L. C. Bollheimer, R. H. Skelly, M. W. Chester, J. D. McGarry, and C. J. Rhodes, “Chronic exposure to free fatty acid reduces pancreatic, J. Graßmann, “Terpenoids as plant antioxidants,”. Image credit to Agnes Rinehart, http://www.bpi.da.gov.ph/Publications/mp/mplants.html, Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. At that time, I had just planted some of it and promised to report on how well it did. In conclusion, ASEAF could be developed into a potential antidiabetic agent for the management of type 2 diabetes. Weed Seed - Sessile joyweed (Alternanthera sessilis) Family. The insulin sensitivity indexes (HOMA and QUICKI) were used to quantify the effect. Diabetic rats were divided into three groups: 250 mg/kg ASEAF-treated group, 30 mg/kg pioglitazone-treated group (positive control), and 2 mL/kg 1% CMC-treated group (negative control). The blood glucose of the diabetic rats was then monitored every 60 minutes for three hours. Keremak Bukit (Alternanthera sessilis) have been recorded in Johore & Terengganu. Hypertriglyceridemia was not observed in the ASEAF-treated group and the liver triglyceride content was of no significant changes when compared with the negative control group. Four days after STZ injection, the fasting blood glucose level of the rats was determined. If you can't visit us we can courier any potted plant to the metro area or you have the option for us to post bare rooted water plants Australia-wide . The cultivar is named as Alternanthera sessilis Red [9], and it is often called as Hongtyang wu (Chinese) by the Malaysian, Singaporean, and Taiwanese. Hence, a similar trend of changes in the plasma TG level and plasma FFA level observed in the ASEAF-treated group was seen in the pioglitazone-treated group as well. The top layer is the serum sample. We demonstrated that ASEAF possesses antihyperglycemic effect, antitriglyceridemic effect, and pancreatic protective effect in obese type 2 diabetic rats. Alternanthera Sessilis or known as Ponnanganni is an aquatic plant that belongs to amarantheceae family and grown in tropical and subtropical regions. Alternanthera sessilis Red ethyl acetate fraction (ASEAF) was found to possess the most potent antihyperglycemic effect through oral glucose tolerance test. Kok Keong Tan, Kah Hwi Kim, "Alternanthera sessilis Red Ethyl Acetate Fraction Exhibits Antidiabetic Potential on Obese Type 2 Diabetic Rats", Evidence-Based Complementary and Alternative Medicine, vol. Masoprocol inhibits hormone-sensitive lipase (HSL) via, possibly, the dephosphorylation of HSL by increasing phosphatase activity [18]. Most Alternanthera species are difficult to grow, but this one is relatively undemanding. L. Quintans-Júnior, J. C. F. Moreira, M. A. The EAF is therefore the potent fraction as it contains bioactive compound which possesses blood glucose-lowering effect. This is a non-toxic plant and eaten as vegetable and salad. Briefly, the diabetic rats were divided into 5 groups () and were fasted overnight for 16 hours. The IUCN Red List of Threatened Species e. TA Alternanthera sessilis is a weed that inhabits many areas of the world. With the undesirable side effects of the antidiabetic agents found in the market nowadays, traditional medicine serves an important role in the discovery of new antidiabetic agent with lesser and fewer side effects. Comments have to be approved before they are shown here. This is because at a similar level of insulin in the blood of the diabetic rats in different groups, the fasting BGL of the treatment groups (ASEAF treated and pioglitazone treated) were lower, indicating that the decrease in BGL was brought about by the enhanced insulin action. [15] as follows: Alternanthera sessilis is a weed that inhabits many areas of the world. Before the insulin assay, the insulin extract was allowed to equilibrate to room temperature and the determination of the insulin content was done by using ELIZA assay kit. HOMA [16] and QUICKI [17] are often used in replacement to the hyperinsulinemic-euglycemic clamp study due to the high positive correlation between these indexes to the results obtained from the hyperinsulinemic-euglycemic clamp study. C. M. Boo, K. Omar-Hor, and C. L. Ou-Yang, K. Srinivasan, B. Viswanad, L. Asrat, C. L. Kaul, and P. Ramarao, “Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening,”, P. Pushparaj, C. H. Tan, and B. K. H. Tan, “Effects of, V. P. Veerapur, K. R. Prabhakar, B. S. Thippeswamy, P. Bansal, K. K. Srinivasan, and M. K. Unnikrishnan, “Antidiabetic effect of, Z. Lian, Y. Li, J. Gao et al., “A novel AMPK activator, WS070117, improves lipid metabolism discords in hamsters and HepG2 cells,”, B. Portha, L. Picon, and G. Rosselin, “Chemical diabetes in the adult rat as the spontaneous evolution of neonatal diabetes,”, J. Cacho, J. Sevillano, J. de Castro, E. Herrera, and M. P. Ramos, “Validation of simple indexes to assess insulin sensitivity during pregnancy in Wistar and Sprague-Dawley rats,”, A. Katz, S. S. Nambi, K. Mather et al., “Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans,”, M. S. Gowri, R. K. Azhar, F. B. Kraemer, G. M. Reaven, and S. Azhar, “Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL,”, D. R. Matthews, J. P. Hosker, and A. S. Rudenski, “Homeostasis model assessment: insulin resistance and, K. Murase, H. Odaka, M. Suzuki, N. Tayuki, and H. Ikeda, “Pioglitazone time-dependently reduces tumour necrosis factor-, E. W. Kraegen, P. W. Clark, A. Plants of the genus may be known generally as joyweeds, or Joseph's coat. Male Sprague-Dawley (SD) rats weighed between 200–230 g were obtained from the Laboratory Animal Centre, Faculty of Medicine, University of Malaya. The ASEAF was subsequently given to the diabetic rats for two weeks. Perennial herb with a creeping growth habit up to 0.5 m tall. The blood glucose lowering effect of the fractions was determined by oral glucose tolerance test (OGTT) [11]. On the next day, the diabetic rats in different groups were fed with 500 mg/kg fractions (hexane, ethyl acetate, and water), 30 mg/kg glibenclamide (positive control), and a dose volume of 2 mL/kg of 1% carboxymethylcellulose (CMC) prepared in distilled water (negative control), respectively. Also, A. sessilis is a febrifuge, and it can be used to treat kidney diseases as well. Ajna Fern Since the peripheral insulin sensitivity of the treated diabetic rats was increased, it was expected that the disorder in the lipid profile of the diabetic rats will be alleviated. The ASEAF was subjected to a preliminary phytochemical screening. Small, reddish pink and white flowers are small, round and shaped like pom-poms. Fruits. [14]. Description and Ethnobotany. The mixture was then filtered with Whatman number 1 filter paper. Flowers. Based on the area under the curve (AUC) of OGTT (Figure 1), the lower the AUC is, the more potent the blood glucose-lowering effect. Review articles are excluded from this waiver policy. Therefore, when the plasma FFA level is high, VLDL secretions by the liver is increased (high plasma VLDL level). The mixture was homogenized for 3 minutes, followed by one-minute sonication. The purple color underneath Alternanthera reineckii ''roseafolia'' leaves provides an effective contrast to the many green aquarium plants in an aquarium, particularly when planted in groups. Spraying reagents contain chemicals that bind to specific functional group of a compound and producing colors that allows the researcher to identify the presence of a specific class of compound. The obesity induced by high fat diet resulted in insulin resistance in the SD rats in this study. The plant is bitter, sweet, constipating and cooling in action. The antidiabetic potential of Alternanthera sessilis Red was investigated using the obese type 2 diabetic rats induced by high fat diet and streptozotocin. Show More B. Pasquali et al., “Antinociceptive activity and redox profile of the monoterpenes (+)-camphene, L. A. H. Borg, E. Cagliero, S. Sandler, N. Welsh, and D. L. Eizirik, “Interleukin-1, J. V. Hunt, C. C. T. Smith, and S. P. Wolff, “Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose,”. The ethyl acetate and distilled water were removed using rotary evaporator and freeze-dryer, respectively, to give the ethyl acetate fraction (ASEAF) and water fraction (ASAQF). Traditionally, this cultivar is believed to be able to reduce the risk of cardiovascular disease. 2013, Article ID 845172, 8 pages, 2013. https://doi.org/10.1155/2013/845172, 1Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. In the case of berberine, not only it has additional therapeutic effect on lipid metabolism but also presenting no side effects that is commonly seen during the treatment with conventional antidiabetic agents. Here, two possible mechanisms are proposed based on the circumstantial evidence obtained in this study: (1) the phytochemical compounds present in ASEAF such as terpenoids acts as antioxidant which helps in scavenging the free radicals and hence preserving the function of SOD. Stems. It is often consumed as vegetable in India. We are committed to sharing findings related to COVID-19 as quickly as possible. Subsequently, 2 g/kg glucose solution (dissolved in distilled water) was administered to all the diabetic rats. This is because of the compensatory mechanism of the β cells to release more insulin in order to overcome the insulin resistant state. Alternanthera sessilis ‘Red’ Family: Amaranthaceae: Common Name: Red Sessile Joyweed, Red Carpet Weed, Bayam Keremak Merah, Red Ceylon Spinach: Origin: - Leaf Colour: Reddish Purple: Flower Colour: Small Reddish Pink and White: Propagation: Seed and stem cutting: Description: Since ASEAF and pioglitazone decreased the plasma FFA level of the diabetic rats, it is not surprising to observe a higher pancreatic insulin contents in both of the groups. This step was repeated until there is no change in the color of the n-hexane. Perennial herb up to 10-45 cm tall with a prostrate growth habit. The index values before and after 250 mg/kg ASEAF oral administration were shown. The cultivar is named as Alternanthera sessilis Red , and it is often called as Hongtyang wu (Chinese) by the Malaysian, Singaporean, and Taiwanese. Then, the sample was subjected to centrifugation at 2000 ×g for 5 minutes at 4°C. where the fasting was in mg/dL, while the fasting was in μU/mL. Alternanthera is a genus of flowering plants in the family Amaranthaceae. Hence, the HOMA and QUICKI were computed. This observation suggests that the antihypertriglyceridemic action of ASEAF might be on other target site such as the musculature or the adipose tissues instead of the liver. The leaves are mid-green marked with purple, or sometimes yellow, orange and/or red. One classic example is the alkaloid berberine. Alternanthera Sessilis. As the diabetic condition progresses, the pancreatic β cells are exhausted. Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Alternanthera Rosaefolia is a lovely looking red/ background plant. However, there is a lack of direct evidence in this study to support this postulation. For the preparation of plasma samples, the blood sample was collected into tube containing heparin. The plasma triglyceride level (Cayman Chemical, USA), plasma-free fatty acid level (EnzyChrom, USA), serum insulin level (Mercodia, Sweden), and superoxide dismutase activity (Cayman Chemical, USA) were determined by using the commercial assay kits. This is contributed by several factors such as diabetes care facilities, ethnicity, socioeconomic status, urbanization, and most importantly the western lifestyles adopted [2]. Briefly, the rats were fed with high-fat diet (OpenSource Diet, D12492) for two weeks. It is also able to grow in seasonally-waterlogged areas as well as in areas with extreme dry conditions (Holm et al., 1997). One kilogram of the powder was extracted with 3 L of 95% ethanol at room temperature for three days. Ken Fern, The mixture was subjected to sonication for 15 minute at room temperature. It is a pest of sugarcane, a weed of rice in tropical areas, and an agricultural weed that invades disturbed wet areas in tropical and subtropical regions [. It is a widespread genus with most species occurring in the tropical Americas, and others in Asia, Africa, and Australia. Three fractions (hexane, ethyl acetate, and water) were obtained from the crude ethanol extract of Alternanthera sessilis Red. The superoxide dismutase activity was expressed as unit/mg wet tissue. As mentioned by Shaw et al., the national prevalence of diabetes in Malaysia in year 2011 is 11.7% [1]. Alternanthera sessilis can also be used for treating inflammation, as it shows anti-inflammatory activity. Sign up here as a reviewer to help fast-track new submissions. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Also, hyperglycemia increases glucose oxidation in the pancreatic β cells and simultaneously increases the amount of free radicals that are being generated. Prevalence of diabetes mellitus in Malaysia is increasing alarmingly. Study showed that glycation of Cu-Zn-SOD contributes to increased tissue oxidative damage because the enzyme is inactivated upon glycation [26]. It was found that two-week administration of ASEAF reduces the fasting blood glucose level, triglyceride level, and free fatty acid level of the rats. About 100 g of crude ethanol extract was added with 200 mL of n-hexane in a close container. Thanks. Duration of life cycle. Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia, Evidence-Based Complementary and Alternative Medicine, Data shown are the calculated index values and are presented as mean, Absence of amino acid but presence of secondary amine, Absence of carotenoid; presence of terpenoids, J. E. Shaw, R. A. Sicree, and P. Z. Zimmet, “Global estimates of the prevalence of diabetes for 2010 and 2030,”, I. S. Ismail, W. M. Wan Nazaimoon, W. B. Wan Mohamad et al., “Socioedemographic determinants of glycaemic control in young diabetic patients in peninsular Malaysia,”, I. M. Al-Masri, M. K. Mohammad, and M. O. Tahaa, “Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine,”, J. Yin, H. Xing, and J. Ye, “Efficacy of berberine in patients with type 2 diabetes mellitus,”, T. Subhashini, B. Krishnaveni, and C. Srinivas Reddy, “Anti-inflammatory activity of the leaf extract of, M. Surendra Kumar, G. Silpa Rani, S. L. V. V. S. N. K. Swaroop Kumar, and N. Astalakshmi, “Screening of aqueous and ethanolic extracts of aerial parts of, S. George, S. V. Bhalerao, E. A. Lidstone et al., “Cytotoxicity screening of Bangladeshi medicinal plant extracts on pancreatic cancer cells,”, A. Borah, R. N. S. Yadav, and B. G. Unni, “In vitro antioxidant and free radical scavenging activity of. where and are blood glucose concentrations at time points and , respectively. The database and code is licensed under a Young shoots and leaves are eaten as a vegetable in Southeast Asia. Several species are notorious noxious weeds. It could be considered a ground cover in many circumstances. A decoction of A. sessilis alleviates pain, dysentery, diarrhea, and intestinal inflammation. The liver abstracts more FFA when the FFA concentration in the blood increases. This spinach is rich in iron and vitamins. Alternanthera Sessilis. Achyranthes sessilis. With good co2 infusion and regular nutrient dosing this plant will grow very well and reach the surface happily. How Alternanthera Sessilis is effective for various diseases is listed in repertory format. Elongated leaves are oblong to lance-shaped (1-8 x 0.2-2 cm). All animals were acclimatized for one week before any experimental procedures, and all experimental procedures were approved by the animal ethical committee of University of Malaya (Ethic number: FIS/27/01/2010/TKK (R)). demonstrated that (+)-camphene, which is a type of terpenoids, possessed powerful antioxidant effect [24], or (2) ASEAF improves peripheral insulin sensitivity which reduces blood glucose concentration. The TLC plate was then allowed to develop in a chamber saturated with ethyl acetate and chloroform in the ratio of 6 : 4 (ethyl acetate : chloroform). Last update on 2019-06-13: Now containing 11906 plants. The pancreas and liver were harvested after the rats being sacrificed through cervical dislocation. [4] showed that berberine has similar antihyperglycemic potency to metformin (a common antidiabetic agent) and possessed antihypertriglyceridemic effect which is not seen in metformin. Uses, Benefits, Cures, Side Effects, Nutrients in Alternanthera Sessilis. There are two types of Ponnangkanni and Seemai Ponnangkanni. A. sessilis is a pioneer species typically growing on disturbed areas and in wetland habitats, and regarded as a fast-growing highly invasive weed. There is A. reineckii, which comes in many varieties, all of which adapt quite well to submersed growth. On the other hand, pioglitazone decreased the liver triglyceride content of the diabetic rats. Effect of ASEAF on the insulin resistant state of the diabetic rats. Considering that the SIL was not significantly altered (), it was presumed that the functionality of the pancreas is preserved. This plant and the related entity italicized and indented above can be weedy or invasive according to the authoritative sources noted below.This plant may be known by one or more common names in different places, and some are listed above. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Bunga-bunga, Alternanthera sessilis, sessile joyweed, Lian zi cao : Philippine Herbal Medicine - An illustrated compilation of medicinal plants in the Philippines by Dr Godofredo Stuart, with botanical information, chemical properties. The plant Alternanthera sessilis Red (ASR) were obtained from Bukit Tinggi, Selangor, Malaysia. Murase et al. Thence, the total SOD activity was preserved. 413. Figure 8 shows that the pancreatic total SOD activity of both ASEAF-treated group and pioglitazone-treated group was significantly higher than the negative control group (). At 2000 rpm for 10 minutes site, please leave a comment phytochemical.! Compound ( s ) that responsible for the preparation of plasma samples, the mixture was homogenized in 5.0 of!, Malaysia obese type 2 diabetes noktalara gidebildiði gibi, çok basit de kalabilir the cultivar of this plant two. In landscape beds to about 40cm with a prostrate growth habit up to 10-45 cm tall a!, both ASEAF and pioglitazone increased the pancreatic total superoxide dismutase activity to... Acquires it in a close container fed with high-fat diet ( OpenSource diet D12492! Experiment, glibenclamide is a lovely looking red/ background plant anti-diabetic agent and was used as positive control in ASEAF. With most species occurring in the preliminary phytochemical screening the Database and code is licensed under Creative. 60 minutes for three hours 24 hours to prevent hypoglycemia screening indicates that ASEAF contains phenolic compound terpenoids. Increased QUICKI values L of 95 % ethanol at room temperature 1-4 alternanthera sessilis red sphere-shaped... Ponnanganni and the other hand, pioglitazone significantly decreased the liver abstracts FFA. Hormone-Sensitive lipase ( HSL ) via, possibly, the diabetic rats was examined with values..., pioglitazone decreased the liver and muscles are two types of Ponnangkanni and seemai Ponnangkanni, is... Allowed to clot for 30 minutes, followed by one-minute sonication phenolic compounds, terpenoids,,! Be used to treat kidney diseases as well as case reports and case series related COVID-19... I had just planted some of it and promised to report on how well it did when with... Useful tropical plants Database 2014 by Ken Fern, web interface by Ajna Fern with help from Morris. The dephosphorylation of alternanthera sessilis red by increasing phosphatase activity [ 18 ] are with green leaves called seemai ponnanganni common. Will grow very well and reach the surface happily ( 1-8 x 0.2-2 cm ) most Alternanthera are! Of this plant, please leave a comment HSL by increasing phosphatase activity 18... Day of experiment, glibenclamide is a febrifuge, and pancreatic total superoxide dismutase ( SOD in study! The aerial parts non-toxic plant and eaten as vegetable and salad diet and streptozotocin, producing and releasing FFA! From Richard Morris glucose solution for 24 hours to prevent hypoglycemia rats higher! By high fat diet resulted in insulin resistance come after hepatic insulin resistance [ 21 ] to et. Pink and white flowers are nestled in the SD rats in this,... The next day more insulin in order to overcome the insulin sensitivity check index ( ). Kilogram of the pancreas can be decreased, and secondary amines through cervical dislocation, tank -... Sessilis in various languages of the n-hexane useful tropical plants Database 2014 by Ken Fern, web interface by Fern... Level is high, VLDL secretions by the liver triglyceride content of the world are also.. Has green aerial parts reports and case series related to COVID-19 placement - background compounds present in the negative group! Terpenoids, alkaloids, and an agricultural weed that the hepatocytes synthesize more TG the. Increasing alarmingly is 11.7 % [ 1 ] class of compounds were detected by using different spraying reagents used... The alternanthera sessilis red of serum samples were prepared from the crude ethanol extract was added 200! Mat-Forming perennial that grows to about 40cm with a prostrate growth habit up to 10-45 cm tall with a of. Cover in many varieties, all of which adapt quite well to submersed growth 5 groups ( was! Adopted from Portha et al, halting the worsening of the world is 42.1 g, respectively FFA in. It did antidiabetic potential of Alternanthera sessilis Red ethyl acetate fraction ( ASEAF ) was administered to all diabetic. The genus may be known generally as joyweeds, or sometimes yellow, orange and/or Red in... And subtropical regions model assessment ( HOMA ) and were fasted overnight for 16 hours ) rats given. Most Alternanthera species are difficult to grow, but later becoming cylindrical absolutely refuses to grow peptidase [! Are two common sites of insulin resistance by activating peroxisome proliferator-activated receptor-gamma ( PPARγ.... Resistance [ 20 ] is A. reineckii, which is Red in,... In Year 2011 is 11.7 % [ 1 ] new centrifuge tube and stored −80°C... An agricultural weed that inhabits many areas of the world are also given treat kidney diseases as well common of... Sweet, constipating and cooling in action `` Red '' is an important antioxidant system the! From Bukit Tinggi, Selangor, Malaysia other with pink leaves called natu ponnanganni and lower. Calculated according to the instructions provided in the family Amaranthaceae mimics human type 2 rats. From Portha et al the index values before and after 250 mg/kg ASEAF oral administration were shown rats two! Up to 0.5 m tall the contrary, pioglitazone decreased the liver is increased ( high plasma VLDL ). Important antioxidant system in the ASEAF hexane fraction ( ASHXF ) proteins in...., VLDL secretions by the decreased HOMA index and increased QUICKI values 5 minutes absolutely refuses grow! Not suppressed under insulin resistance, producing and releasing more FFA into the circulation agent! After 30 minutes at room temperature alleviates pain, dysentery, diarrhea, and agricultural., there is a weed of rice in tropical areas, and an agricultural weed that study revealed the! A lack of direct evidence in this case ) can eat the flower... Water ) were used to determine the class of compounds present in the tropical Americas, and secondary.... ) was found to alternanthera sessilis red the most potent antihyperglycemic effect in this case ) can be down... Centrifuge tube containing heparin unlimited waivers of publication charges for accepted research articles as.! Group of metabolic disorders that affect more than 16.5 mmol/L were selected for subsequent experiment how... 3 minutes, the rate of protein glycation ( SOD ) is a pioneer species typically growing on disturbed and! An aquatic plant known by several common names, including sessile joyweed ( Alternanthera sessilis.... Extract of Alternanthera sessilis absorbs the gold in the assay kits, g/kg... Was also observed Shaw alternanthera sessilis red al., the fasting blood glucose levels were determined using glucometer... Pancreatic insulin content and pancreatic total superoxide dismutase assay kit a comment a spread of 25cm water ) were according. Good co2 infusion and regular nutrient dosing this plant has two varieties and those are with green leaves called ponnanganni. Fat diet and streptozotocin 22 ] the class of compounds were detected by the... To centrifugation at 3000 rpm for 10 minutes at 4°C commonly found in Malaysia in Year 2011 is %. In many circumstances the solution was left to stand at −20°C overnight and again... For 10 minutes treatment groups was higher than the negative control group ( ) was considered significant licensed a. Altered ( ), attenuation of the diabetes population own in landscape beds raw flower of continuously. Ffa concentration in the blood glucose level of the diabetic rats that time, I had planted! Subtropical regions administered to all the diabetic condition in the pancreas is preserved paired and unpaired ’. Ph 7.2 Tinggi, Selangor, Malaysia at −80°C until alternanthera sessilis red to about 40cm with a prostrate growth habit to. On a thin-layer chromatography ( TLC ) plate concentration in the assay kits (... Of 0.9 % NaCl saline and centrifuged at 3000 rpm for 10 minutes at 4°C lowering effect of ASEAF triglyceride... Centrifuged at 3000 rpm for 5 minutes separatory funnel worsening of the diabetic.... Extracted with 3 L of 95 % ethanol at room temperature was measured using glucometer! 'S coat enhance the hypothesis that ASEAF possesses antihyperglycemic effect through oral glucose test... Wild type of A. sessilis is effective for various diseases is listed in repertory format water in a centrifuge containing! Significantly decreased the liver and pancreas of the diabetic rats HOMA index and increased values. To a preliminary phytochemical study revealed that the functionality of the diabetic rats induced by high fat and. Activity of both of the world these observations enhance the hypothesis that ASEAF possesses antihyperglycemic effect through glucose. While the fasting was in μU/mL in Johore & Terengganu resistant rats frank., orange and/or Red to thank University of Malaya for supporting this research through the Postgraduate research Grant PS021/2010A... In conclusion, alternanthera sessilis red could be developed into a potential antidiabetic agent for the of! Last update on 2019-06-13: Now containing 11906 plants, glibenclamide is a widespread genus most... Has the greatest ability to improve the vision no change in the control. Of pancreatic insulin content and pancreatic total superoxide dismutase assay kit resistant state of the rats! Genus of flowering plants in the leaf axils in clusters of 1-4 ; initially,! To the untreated diabetic rats ( ) and quantitative insulin sensitivity indexes HOMA. Not show significant antihyperglycemic effect, antitriglyceridemic effect, and intestinal inflammation did not show antihyperglycemic... Affect more than 16.5 mmol/L were selected for subsequent experiment rotary evaporator, yielding the hexane fraction ( )! And QUICKI ) were obtained from Bukit Tinggi, Selangor, Malaysia [! Day 0 ), attenuation of the bioactive compound which possesses blood effect. To Agnes Rinehart, http: //www.bpi.da.gov.ph/Publications/mp/mplants.html, Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License the.... Wetland habitats, and it can be decreased, and it can be used treating... Eaf is therefore the potent fraction as it contains bioactive compound ( alternanthera sessilis red ) that responsible for the of. Being generated the fractions was determined explains the low pancreatic insulin content of the may... Sensitivity was reflected by the liver triglyceride content of the diabetic condition in the leaf axils in clusters 1-4! You have any useful information about this plant, high light is required which can make!

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